Recent executive-level company changes and promotions in the biopharma, medical device and diagnostics industries.

Fecal incontinence is a common, devastating condition that often goes untreated. Eyeing the potential multibillion-dollar opportunity, medtech start-ups are developing approaches that range from small and disposable to surgical and permanent.

This Month's Profile Group, Skin Is In With Biomedical Investors, features profiles of Aclaris Therapeutics, Alexar Therapeutics, Rogne Bioscience, and Scioderm. Plus these Start-Ups Across Health Care: Harpoon Medical, OcuSciences, Oncoceutics, Pelvalon, and Procyrion.

Pelvalon Inc.'s Eclipse System, a non-surgical vaginal insert for fecal incontinence in women, is composed of an inflatable balloon attached to a base. When inflated via a handheld pump connected to the device, the balloon exerts pressure on the vaginal wall, thus compressing the rectum to prevent stool from passing.