The world is waking up to aptamers. With a few big deals and a small flock of products in the clinic, aptamers' boosters see the molecules largely replacing antibodies; they've got many of the advantages of both large and small molecules, plus the added advantage of speedy creation. But they still face major technological challenges-including high manufacturing costs, limited half-lives, and problems with intracellular targets. The three players whose strategies we profile here-Corgentech, Coley and Archemix--have all chosen to pursue opportunities with aptamers which avoid their biggest problems. But the solutions also limit these companies' abilities to fully exploit the aptamer platform.
By Roger Longman
The pharmaceutical industry, it's fair to say, hasn't completely gotten over its infatuation with small molecules. But it is by no means any longer wedded to them.
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