1. In Vivo

Isis: Pondering Platform Power

The January 2008 collaboration Isis forged with Genzyme was transformative for Isis and a desperately sought-after validation of the antisense field. But unlike its brethren in oligonucleotide drug development -- and most biotechs, for that matter -- Isis rejects the notion of commercializing its products. The deal sets up a paradox: Can Isis remain a platform company once investors' focus is on a product and its trajectory? In a sense, can it stay small?

Mark L. Ratner

In an IN VIVO article last spring, John Maraganore, PhD, president and CEO of Alnylam Pharmaceuticals Inc., wrote that pharma-biotech dealmaking was in some measure stalled because of the...

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