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Alzheimer's Development Financing: Risky Therapies Call for Innovative Deals

 
• By Chris Morrison

Eli Lilly has hedged its bets on its two late-stage Alzheimer's disease candidates. In a deal with TPG-Axon and Quintiles' partnering group NovaQuest, Lilly sheds risk (and potentially reward) in this notoriously difficult therapeutic space. A model for private equity / pharma deals going forward?

The late-August hiccup in Bristol-Myers Squibb Co. and Pfizer Inc.’s development plan for the oral Factor Xa inhibitor apixaban may only cause a short delay to the expected blockbuster anti-clotting drug. On the other hand, it may be a harbinger of more painful clinical snafus to come. But whatever the eventual outcome for apixaban, right now Bristol looks pretty smart for partnering the drug for a handsome fee last April. [See Deal]

While Bristol has made hedging its late-stage bets a mantra—and a significant means to generate development capital, thanks to upfront...

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