Spirus Medical Inc. has developed spiral endoscopy technology that it says enables better access to the gastrointestinal tract for diagnosing and treating GI disorders. The company's platform converts rotational movement into forward advancement, causing its devices to be drawn into, rather than pushed into the body.

Varix Medical Corp.'s novel approach to treating chronic venous insufficiency, better known as varicose veins, uses endovenous water vapor (steam) instead of surgical stripping, radiofrequency energy or laser light to shrink and destroy veins. The start-up's goal is to be the only company to offer a minimally invasive technology that treats most of the veins in the legs, unlike competing modalities that are limited to treating one type of varicose vein.

Nightingale-EOS Ltd.'s Beam Profile Reflectometry technology evaluates coatings on medical devices by measuring the interference effects caused by the interaction of light reflecting from the coating surface with that from the substrate surface. The company's first focus is on implanted cardiac devices, primarily drug-eluting stents, where BPR can measure the concentration of the drug within the film of the coating.