1. In Vivo

Biosimilar Remicade Will Pit Rising Cost Pressures Against Prescriber Caution

If approved in Europe this year, as expected, Celltrion/Hospira’s biosimilar infliximab will provide a compelling test of whether and how quickly budgetary pressures can override physician caution. It will also set the stage for the $70 billion worth of copycat antibodies in development.

The forthcoming European approval of Hospira Inc./Celltrion Inc.’s biosimilar infliximab – a copy of rheumatoid arthritis drug Remicade – is an important date on the biosimilars calendar. Assuming, as most do, that the European Medicines Agency (EMA) will give it the nod, the drug – which Celltrion will co-market in the EU 27 as Remsima and Hospira will sell as Inflectra – will be the first biosimilar mAb to reach Europe, or any Western developed market. The first of a wave of complex biosimilars, mostly monoclonal antibodies, it could generate far more exciting returns than seen for first-generation copycat biologics such as erythropoietin (EPO) or filgrastim.

The case in favor of biosimilars looks even more compelling in the midst of the deepest and longest economic recession...

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