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SYMPLICITY Results Make Life Difficult For Renal Denervation Programs

The big slice of the device industry, from large-cap firms to venture capitalists, with some stake in the renal denervation opportunity are trying to understand the new reality now that Medtronic’s pivotal Symplicity renal denervation device trial missed its endpoint.

Medtronic PLC’s bombshell news, the disappointing clinical results for its Symplicity renal denervation product, left a smoking crater on the medtech landscape during last week’s JP Morgan Healthcare Conference in San Francisco. Large-cap executives and venture capitalists who saw great promise in the new therapeutic approach spent time trying to gauge the size and scope of the damage on the medtech industry and their own particular portfolios.

The SYMPLICITY HTN-3 trial followed two successful trials that demonstrated efficacy for the approach of ablating nerves within the renal...

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