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IO Combos By The Numbers

 
• By Amanda Micklus and Jim Kling

Over the past five years, pharma companies have cast an increasingly wide research net in search of cancer immunotherapy drug combinations that can help patients who have failed monotherapies.

Cancer immunotherapy has reshaped the oncology space. The drugs, which block a key mechanism among tumors that allows them to escape the attack of the immune system, have achieved long-lasting benefits in some patients, and activities across a broad array of tumor types. For all the good news, the drugs help only a small percentage of patients. Over the past five years, that wide applicability and frustratingly limited response has driven pharma companies to cast a wide research net in search of drug combinations that could produce a response in patients who fail monotherapies. (See Exhibit 1.)

“The obvious question is, 'are there approaches which can augment a response or excite a response in a patient who...

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