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GSK Woes Raise Big Pharma R&D Question

 
• By Melanie Senior

GSK's various thwarted efforts to boost productivity through R&D revamps begs the question whether big pharma should be trying to do in-house discovery and early development at all.

Back in 2000, newly merged GlaxoSmithKline PLC began to reorganize its R&D to boost productivity. Over the following decade and a half, the big pharma experimented with variously sized discovery units, oversight structures and incentive systems designed to create biotech-like innovation within its walls. (See Exhibit 1.)

It was a ripe time to try. Scientific discovery has flourished since the turn of the century. Genomics and gene-editing tools and other new technologies and advances in data science...

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