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‘We’re On The Edge Of Knowledge,’ Says Dewpoint CEO

 
• By Ben Comer

Biomolecular condensates were first observed over 100 years ago, but their function – and the role they might play in a broad range of diseases – is only now being rigorously explored by drug developers. New technological development is helping scientists recreate condensates in laboratory conditions, providing insight into fundamental cellular processes. Amir Nashat, CEO of Dewpoint Therapeutics, told In Vivo that the company, following a recent $77m series B round, now has the resources to get to proof of concept for drugs targeting biomolecular condensates.

Bubbles
• Source: Shutterstock

Dewpoint Therapeutics, with headquarters in Cambridge, Massachusetts and Dresden, Germany, believes understanding and targeting biomolecular condensates – droplets without membranes that form in the cell through a process called phase separation – represents the next “tectonic shift” in drug discovery. With 16 years at investment firm Polaris Partners and multiple start-up CEO roles under his belt, CEO Amir Nashat, who received an Sc.D from Massachusetts Institute of Technology (MIT) in chemical engineering and a biology minor under the tutelage of MIT’s Bob Langer, said he’s never seen anything “so architecturally relevant … to everything in biology.”

The condensate space, said Nashat, “is probably more fundamental to a better understanding of how cells function, and how cell...

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