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New Treatment Modalities: Protein Degraders And Molecular Glues Gain Traction

Taking Aim At Recalcitrant Targets

 
• By John Davis

In 2020, investors poured millions of dollars into biotech companies searching for new therapeutics that interact with cellular processes involving the destruction and recycling of cellular proteins. These protein degradation-targeted therapies, and molecular glues, have been attracting the attention of big pharma too.

Test tubes
• Source: Shutterstock

Walking in the woods in the UK would more than likely reveal ash trees marked with colored paint, flagged for felling because of the presence of the lethal “ash dieback” fungus, Hymenoscyphus fraxineus. Having a system of identifying and sorting healthy from diseased trees seems to work well for managing timbered areas – the tagging is specific and tailored to the problem at hand.

The process is not dissimilar to what happens in human cells. Throughout the animal kingdom, a way of marking unneeded or damaged proteins for cellular recycling has also evolved, the...

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