Oncology Market Trends: Predictive Biomarkers, New IO Targets And Tougher Competition

 
• By Mark Ratner

Higher success rates in rare cancers, where biomarkers can better direct therapy, characterize the oncology treatment landscape. Deal-making is favoring alliances over acquisitions as drugmakers focus on establishing the clinical benefit of new targets, particularly for rare indications.

Cancer cells on scientific background.3d illustration

Four of the current top 10 selling drugs treat cancer, led by the immuno-oncology drugs Keytruda (pembrolizumab) and Opdivo (nivolumab), along with Revlimid (lenalidomide) and Imbruvica (ibrutinib). Meanwhile, challenged by biosimilars, sales of Roche Holding AG/Genentech, Inc.’s trio of foundational antibody drugs Avastin (bevacizumab), Herceptin (trastuzumab) and Rituxan (rituximab) are sliding (see Exhibit 1).

IO based on PD-1/PD-L1 checkpoint inhibition is firmly established in the first-line treatment of many solid tumors (with the notable...

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