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The Journey Has Just Begun For LAG-3 Therapeutics

 
• By Jo Shorthouse

Clinical stage innovator Immutep talks to In Vivo about the potential for LAG-3 antibodies in cancer and autoimmune diseases.  

Journey
• Source: Shutterstock

Data from LAG-3 trials caused a stir at the 2021 ASCO meeting, with promising clinical data in this third class of checkpoint inhibitor presented by firms such as Regeneron Pharmaceuticals, Inc., Merck & Co., Inc. and – with a different approach - Immutep Ltd. (Also see "ASCO Offers Glimpse Of LAG-3 Inhibitors’ Potential Opportunities – And Limitations" - Scrip, 7 June, 2021.)

In the year since, the FDA has approved Bristol Myers Squibb Company’s LAG-3 blocker relatlimab in a fixed-dose combination with Opdivo (nivolumab) for unresectable or metastatic melanoma, the first...

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