The ranks of B7-H3-targeting antibody-drug conjugates under development in China have seen their first dropout, although elsewhere there are two FGFR2b-directed ADCs with first-in-class potential on the horizon. Meanwhile, there have been other discontinuations of KRAS G12C inhibitors and anti-BCMA CAR-T cell therapies in the country, while new players have surfaced in the areas of mRNA cancer vaccines and amyloid-beta-targeting antibodies for Alzheimer’s disease.

Along with latest results, Kenvue says as its “transitions services agreement” with J&J ends, its board approves reducing global workforce by around 4%. It expects around $275m in pre-tax restructuring costs in both 2024 and 2025 without changes to its capital allocation priorities.

Advances in synthetic biology are moving biopharma closer to a world where treatments can be tailored while remaining cost-effective.

J&J executives are confident the proposal to pay plaintiffs making ovarian cancer claims a total of $6.48bn over 25 years will be accepted, resolving 99.75% of those lawsuits pending against it and US affiliates. The proposal allows individual plaintiffs direct say on whether to accept it.